Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle
MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes. Associated with EVs, extracellular miR-136-3p may serve as a molecular messenger to communicate islet-skeletal muscle crosstalk after exercise. Extracellular miR-136-3p may serve as a molecular messenger to communicate islet-skeletal muscle crosstalk. Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.
Authors
- Juleen Rae Zierath (ORCID: https://orcid.org/0000-0001-6891-7497)
- Oscar P. B. Wiklander (ORCID: https://orcid.org/0000-0003-1176-8114)
- Romain Barrès (ORCID: https://orcid.org/0000-0002-0158-519X)
- E Caria
- A. Sanz (ORCID: https://orcid.org/0000-0002-8122-0069)
- Samir EL Andaloussi (ORCID: https://orcid.org/0000-0003-4468-9113)
- Anna Krook (ORCID: https://orcid.org/0000-0002-0891-0258)
- Dimitri Van Simaeys (ORCID: https://orcid.org/0000-0003-3457-761X)
- Per‐Olof Berggren (ORCID: https://orcid.org/0000-0001-8991-413X)
- Mutsumi Katayama
- Kenneth Caidahl (ORCID: https://orcid.org/0000-0002-5079-9696)
Institutions
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jshs.2025.101091
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- European Foundation for the Study of Diabetes
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Novo Nordisk Fonden
- East China Institute of Technology