Evaluation of the gut microbiome and sex hormones in postmenopausal women with newly diagnosed hormone receptor-positive breast cancer versus healthy women: a prospective case-control study
This pilot study showed differences in the gut microbiome and endogenous progesterone levels among postmenopausal women with hormone receptor-positive breast cancer compared with healthy controls. These interesting findings may have implications for breast cancer risk and prevention and warrant further exploration.
Authors
- Jonas Schlüter (ORCID: https://orcid.org/0000-0002-6214-9367)
- Grant Hussey (ORCID: https://orcid.org/0000-0003-0544-8237)
- Adriana Heguy (ORCID: https://orcid.org/0000-0002-2836-6683)
- Martin J. Blaser (ORCID: https://orcid.org/0000-0003-2447-2443)
- Sylvia Adams (ORCID: https://orcid.org/0000-0003-4737-1952)
- Ezeddin Fadel
- Karina Martínez‐Flores (ORCID: https://orcid.org/0000-0003-0675-0227)
- James L. Speyer
- Maryann Kwa (ORCID: https://orcid.org/0000-0003-4708-1381)
- Ruth Oratz (ORCID: https://orcid.org/0000-0002-7708-1043)
- Adrian A. Franke (ORCID: https://orcid.org/0000-0002-1911-1662)
- Angelina Volkova (ORCID: https://orcid.org/0000-0003-1343-6826)
- Yelena Novik (ORCID: https://orcid.org/0000-0002-2431-8764)
- Komal Jhaveri
- Kelly V. Ruggles
- Marleen Meyers
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Hawaiʻi at Mānoa (US)
- University of Hawaii System (US)
- Memorial Sloan Kettering Cancer Center (US)
- Cancer Center of Hawaii (US)
- New York Genome Center (US)
- University of Hawaii Cancer Center
- New York University (US)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1007/s00432-025-06338-z
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Dyson Foundation
- National Institutes of Health