Tubuloside B alleviates con A-induced acute liver injury by inhibiting the IL-23/JAK2/STAT3 signaling pathway hyperactivation during Th17 cell differentiation
Collectively, our findings demonstrate that TB alleviates Con A-induced ALI by blocking the IL-23/JAK2/STAT3 signaling axis during Th17 cell differentiation, thereby attenuating IL-17-mediated hepatic inflammation. This study highlights TB as a potential natural therapeutic candidate for ALI and suggests its potential application in mitigating autoimmune hepatitis (AIH) progression.
Authors
- Ziteng Wang (ORCID: https://orcid.org/0000-0001-7763-8959)
- Mengqi Li (ORCID: https://orcid.org/0000-0002-9731-5919)
- Lingling He (ORCID: https://orcid.org/0000-0001-8082-8788)
- Herui Wei
- Fan Xiao (ORCID: https://orcid.org/0000-0002-2399-6977)
- Jing Luo (ORCID: https://orcid.org/0000-0002-1954-5671)
- Wen An (ORCID: https://orcid.org/0000-0002-1895-1950)
- Zhe Yu
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Ditan Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.intimp.2025.115586
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80