Evaluation of cumulative radiation burden and associated risk in smouldering multiple myeloma patients monitored using recurrent whole-body low-dose CT imaging
The theoretical radiogenic risk of cancer induction associated with multiple WBLDCT examinations for the active surveillance of a real-life SMM cohort appears to be two orders of magnitude lower than 10 % of SMM patients, which may progress to symptomatic MM requiring treatment. Dose optimisation is recommended for the WBLDCT protocol, as well as a patient-specific strategy for active SMM surveillance, but further research is needed to evaluate the role of early therapeutic interventions.
Authors
- Pascaline Wangechi Abissi
- Vasileios-Petros Agrokostas
- Georgia Lymperopoulou
- Vassilis Koutoulidis (ORCID: https://orcid.org/0000-0001-6281-8586)
- Martin Fiebich (ORCID: https://orcid.org/0000-0001-6596-8774)
- Lia A. Moulopoulos (ORCID: https://orcid.org/0000-0001-6009-1088)
- Evangelos Terpos (ORCID: https://orcid.org/0000-0001-5133-1422)
- Panagiotis Grigoropoulos (ORCID: https://orcid.org/0000-0002-0733-1377)
- Ioannis Seimenis (ORCID: https://orcid.org/0000-0003-3665-5271)
Institutions
- National and Kapodistrian University of Athens (GR)
- Technische Hochschule Mittelhessen (DE)
Publication Details
- Journal
- Physica Medica
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.ejmp.2025.105173
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00