Dеvеlоpmеntаl nеurоtоxісіty study оf pesticide Асеtаmіprіd in Wistar Hannover rats

Available data on pesticide Acetamiprid (ACE) are insufficient to clarify the uncertainties identified neurotoxicity. The current DNT study of ACE was conducted according to the OECD TG 426 and GLP requirements to clarify uncertainties. ACE was administered orally by gavage Wistar Hannover rats at dose levels of 0, 2.5, 10 and 45 mg/kg/bw/day. Maternal toxicity was expressed at a dose level of 45 mg/kg/bw/day. Developmental toxicity was indicated at a dose level of 45 mg/kg/bw/day. Regarding ACE developmental neurotoxicity, administration at 10 and 45 mg/kg body weight/day affected the acoustic startle response and locomotor activity, with no observed structural brain changes. Based on the study findings, the No-Observed-Adverse-Effect Level (NOAEL) for maternal toxicity was determined to be 10 mg/kg bw/day. The NOAEL was identified as 2.5 mg/kg bw/day for developmental neurotoxicity. A developmental neurotoxicity study of ACE demonstrated that neurotoxicity is a critical limiting factor for the compound's overall toxicity.