Bazi Bushen capsule alleviates skin photoaging by targeting the KEAP1–NRF2 pathway
This study demonstrates the therapeutic potential of BZBS in combating skin photoaging by modulating the KEAP1-NRF2 pathway. Notably, we identified two novel natural compounds in BZBS-verbascoside and epimedin A-that specifically target and bind to KEAP1. These findings offer a promising therapeutic strategy for alleviating skin photoaging through traditional Chinese medicine and provide valuable insights into the anti-aging mechanisms of composite drugs.
Authors
- Yiling Wu (ORCID: https://orcid.org/0000-0002-1882-0184)
- Ting‐Guo Kang (ORCID: https://orcid.org/0000-0003-3754-2420)
- Yuxuan Jiang
- Kunxu Niu
- Yunlong Hou (ORCID: https://orcid.org/0000-0002-6989-8221)
- Xiaohong Lu (ORCID: https://orcid.org/0000-0001-6417-0250)
- Runtao Zhang
- Liangxing Zhou
- Hongrong Li (ORCID: https://orcid.org/0000-0001-8819-3246)
- Yawen Li (ORCID: https://orcid.org/0000-0003-4822-2254)
- Mengnan Li (ORCID: https://orcid.org/0000-0001-7461-3254)
- Zhiqin Zhao
- Zhifang Guo
- Xingyu Xing
Institutions
- Hebei Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Shijiazhuang University (CN)
- Hebei Yiling Hospital (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.phymed.2025.157360
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.61