Chronological survival improvement over time with oxaliplatin-based chemotherapy plus targeted agents in metastatic colorectal cancer: An ARCAD database study
We demonstrated progressive improvements in survival outcomes for patients with metastatic colorectal cancer receiving first-line oxaliplatin-based chemotherapy plus molecular targeted agents. The findings highlight the importance of biomarker-driven treatment strategies and the evolving role of subsequent therapies in optimizing clinical outcomes.
Authors
- J. Randolph Hecht (ORCID: https://orcid.org/0000-0003-2277-4157)
- Kentaro Yamazaki
- Yoshihiko Maehara (ORCID: https://orcid.org/0000-0002-1532-3537)
- Kohei Shitara (ORCID: https://orcid.org/0000-0001-5196-3630)
- Jean-Yves Douillard
- Toshihiro Misumi (ORCID: https://orcid.org/0000-0001-8339-2895)
- Volker Heinemann (ORCID: https://orcid.org/0000-0002-1349-3321)
- Leonard B. Saltz (ORCID: https://orcid.org/0000-0001-8353-4670)
- Alan P. Venook (ORCID: https://orcid.org/0000-0001-9749-6548)
- Hideaki Bando (ORCID: https://orcid.org/0000-0001-5041-2765)
- Cornelis J.A. Punt (ORCID: https://orcid.org/0000-0003-0846-1445)
- Qian Shi (ORCID: https://orcid.org/0000-0002-4640-8832)
- Masashi Wakabayashi (ORCID: https://orcid.org/0009-0001-6368-5671)
- T. Nishikawa (ORCID: https://orcid.org/0000-0001-6586-6604)
- Takayuki Yoshino (ORCID: https://orcid.org/0000-0002-0489-4756)
- Eiji Oki (ORCID: https://orcid.org/0000-0002-9763-9366)
- Carsten Bokemeyer (ORCID: https://orcid.org/0000-0001-6071-7810)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Eric Van Cutsem (ORCID: https://orcid.org/0000-0002-6372-1230)
- Hans‐Joachim Schmoll (ORCID: https://orcid.org/0000-0001-8705-0593)
- Heinz-Josef Lenz
- Kazumasa Yamamoto (ORCID: https://orcid.org/0009-0005-4085-0741)
- Aimery de Gramont
- Miriam Koopman
- Goro Nakayama
Institutions
- University of Pisa (IT)
- University of Southern California (US)
- Memorial Sloan Kettering Cancer Center (US)
- Universität Hamburg (DE)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Oita University (JP)
- Utrecht University (NL)
- Universitair Ziekenhuis Leuven (BE)
- University Medical Center Utrecht (NL)
- LMU Klinikum (DE)
- Sorbonne Université (FR)
- Shizuoka Cancer Center (JP)
- Kyushu University Hospital (JP)
- University Medical Center Hamburg-Eppendorf (DE)
- USC Norris Comprehensive Cancer Center (US)
- Centre de Recherche Saint-Antoine (FR)
- Institut Hospitalier Franco Britannique (FR)
- National Cancer Center Hospital East (JP)
- Mayo Clinic in Florida (US)
- Nagoya University (JP)
- Martin Luther University Halle-Wittenberg (DE)
- University of San Francisco (US)
- Ludwig-Maximilians-Universität München (DE)
- KU Leuven (BE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.ejca.2025.116034
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00