Modulation of TLR4-mediated inflammatory pathways and oxidative stress by cerium oxide nanoparticles in traumatic brain injury
The study establishes that CeO<sub>2</sub> exert neuroprotection through following mechanisms: (1) TLR4-mediated anti-inflammatory action and (2) catalytic ROS scavenging. Notably, we identify TLR4 modulation as a previously unrecognized therapeutic target of CeO<sub>2</sub> in TBI. These findings position CeO<sub>2</sub> as a promising multitarget nanotherapeutic for TBI that can treat neuroinflammation and oxidative stress - two principal drivers of secondary injury simultaneously. This research provides groundbreaking evidence for the development of CeO<sub>2</sub> based neuroprotective strategies and offers potential advantages over current pharmacological approaches under clinical evaluation.
Authors
- Mohammad Khaksari (ORCID: https://orcid.org/0000-0003-0770-4281)
- Sedigheh Amiresmaili (ORCID: https://orcid.org/0000-0002-7158-4096)
- Ladan Amirkhosravi (ORCID: https://orcid.org/0000-0001-9174-1426)
- Mohammad Abbas Bejeshk (ORCID: https://orcid.org/0000-0002-1372-1590)
- Mohammad Amin Rajizadeh (ORCID: https://orcid.org/0000-0001-6708-1720)
- Mehrdad Khatami (ORCID: https://orcid.org/0000-0002-7519-6998)
- Mohadeseh Chahkandi
- Fatemeh Bagheri (ORCID: https://orcid.org/0000-0003-3484-4562)
Institutions
- Tarbiat Modares University (IR)
- Kerman University of Medical Sciences (IR)
- Iranian Legal Medicine Organization (IR)
- Bam University of Medical Sciences (IR)
- Zahedan University of Medical Sciences (IR)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111567
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00