Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study
Saffron extract supplementation do not affect subclinical depressive symptoms, either as a composite score or individual symptom categories. A potential effect on improved mental health outcomes cannot be excluded but requires further replication in future well-powered trials. This trial (Saffromfood study) is registered at clinicaltrial.gov as NCT05690126 (https://clinicaltrials.gov/study/NCT05690126?term=NCT05690126&rank=1).
Authors
- Fulvio Mattivi (ORCID: https://orcid.org/0000-0003-4935-5876)
- Massimo Farneti
- Sandra Dexpert (ORCID: https://orcid.org/0000-0003-2545-145X)
- David Gaudout (ORCID: https://orcid.org/0000-0002-3255-8274)
- Camille Amadieu (ORCID: https://orcid.org/0000-0003-3359-9315)
- Line Pourtau (ORCID: https://orcid.org/0000-0003-3315-2222)
- Andrea Anesi (ORCID: https://orcid.org/0000-0002-9334-2610)
- Lucile Capuron (ORCID: https://orcid.org/0000-0002-2060-5918)
- Nathalie Castanon (ORCID: https://orcid.org/0000-0002-0079-0562)
- Quentin Leyrolle (ORCID: https://orcid.org/0000-0002-0763-1433)
- Juliette Montet
- Eva Bruchet
Institutions
- Fondazione Edmund Mach (IT)
- Université de Bordeaux (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Complexité, Innovation et Activités Motrices et Sportives (FR)
- NutriNeuro (FR)
- Institut Polytechnique de Bordeaux (FR)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.09.050
- Citations
- 2
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.09