Trem2+ Macrophages Alleviate Renal Tubule Lipid Accumulation and Ferroptosis in Diabetic Nephropathy by Repressing IL-1β–Mediated CD36 Expression
Levels of triggering receptor expressed on myeloid cells 2 (Trem2) in macrophages are increased in human patients and in mice with diabetic nephropathy. Trem2 suppresses the extracellular signal-regulated kinase signaling pathways, thereby inhibiting IL-1β production in macrophages. Macrophage Trem2 deficiency exacerbates tubular cell lipid deposition and ferroptosis by increasing CD36 expression in an IL-1β-dependent manner.
Authors
- Jiaona Liu (ORCID: https://orcid.org/0000-0001-5530-3533)
- Qihu Li
- Guangyan Cai (ORCID: https://orcid.org/0009-0000-4446-1819)
- Xuefeng Sun (ORCID: https://orcid.org/0000-0003-2984-8905)
- Yan Tong (ORCID: https://orcid.org/0000-0002-7610-8259)
- Quan Hong (ORCID: https://orcid.org/0000-0002-6839-7695)
- Jiayi Wan (ORCID: https://orcid.org/0000-0002-8485-6898)
- Qing Ouyang (ORCID: https://orcid.org/0000-0001-8729-1290)
- Wang Xue
- Chao Wang (ORCID: https://orcid.org/0009-0001-5959-7089)
- Xu Wang (ORCID: https://orcid.org/0000-0003-4254-4244)
- Yulan Chen (ORCID: https://orcid.org/0009-0006-5006-6675)
- Xiangmei Chen (ORCID: https://orcid.org/0000-0001-8774-6021)
Institutions
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Chinese PLA General Hospital (CN)
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-10-03
- DOI
- https://doi.org/10.2337/db25-0282
- Citations
- 5
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 10.29
Funders
- National Natural Science Foundation of China