Revealing the molecular mechanisms underlying Xuebijing against sepsis and septic acute kidney injury via bioinformatics and experimental approaches
XBJ exerted therapeutic effects on sepsis and septic-AKI through suppression IL-1β/MMP9, IL-6/MMP9 and TNFα/MMP9 at both mRNA and protein level. This study provides a pharmacological basis for further validating the therapeutic mechanism of XBJ in treating sepsis and septic-AKI by in vitro and in vivo experiments.
Authors
- Xing Li (ORCID: https://orcid.org/0000-0001-8443-5199)
- Gabriel Mbuta Tchivelekete (ORCID: https://orcid.org/0000-0001-6538-789X)
- Xinhua Shu (ORCID: https://orcid.org/0000-0003-3760-3019)
- Weijian Yan (ORCID: https://orcid.org/0000-0003-0057-543X)
- Le Wang (ORCID: https://orcid.org/0000-0003-2107-2743)
- Ke Ren (ORCID: https://orcid.org/0000-0002-6485-1619)
- Juan Tang (ORCID: https://orcid.org/0000-0003-2309-5842)
- Yi Guo
- Matúš Baran
- Yang Bai (ORCID: https://orcid.org/0009-0002-6148-7433)
Institutions
- Glasgow Caledonian University (GB)
- Shaoyang University (CN)
- University of Namibia (NA)
- The Central Hospital of Shaoyang (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1371/journal.pone.0333478
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shaoyang University
- National College Students Innovation and Entrepreneurship Training Program