P06.10.B POSTOPERATIVE COGNITIVE TRAJECTORY OF PATIENTS WITH GIANT IDH MUTATED GLIOMAS

Abstract BACKGROUND IDH mutated gliomas are in many instances causing cognitive impairment already at time of diagnosis. In addition, the treatment may also cause cognitive decline. The negative cognitive impact may potentially be higher in the largest tumors, but there has been limited research on the cognitive effects of giant (≥ 100 ml) IDH mutated tumors. We aimed to study the 1-year trajectories of cognitive functions in patients with giant IDH mutated gliomas after resective surgery MATERIAL AND METHODS This was a prospective, population-based study in patients with giant (≥ 100 ml) IDH mutated gliomas. A cognitive test battery was used to assess cognitive performance in the domains executive function, memory, visuospatial function, language, processing speed and attention. Preoperative test reslts were compared with three month and 12 month postoperative test results, respectively, excluding executive and visuospatial function at three months postoperative (shorter test battery at three months). Both individual and domain-level analyses were done. RESULTS Eighteen patients were included. Median age was 44.5 years (40.2-54.2). Ten patients were male (55.6%). Median tumor volume was 125.3 ml (113-135), and median extent of resection was 86.3% (72%-92.3%). At three months for the domains, improvements were seen in memory (p < 0.05) and processing speed (p < 0.05). No significant cognitive test or domain changes were seen when comparing baseline with performance at 12 months after surgery. CONCLUSION Despite the intimidating size, cognitive trajectories are favorable in giant IDH mutated gliomas. The limited sample size limits us from drawing firm conclusions.