Multiplexed Imaging Mass Cytometry Reveals Tumor-immune Microenvironment–dependent Hormone Receptor Expression in Adult-Type Ovarian Granulosa Cell Tumors
We discovered two histologically and molecularly distinct forms of AGCTs that differ in cell composition, immune activity, and hormone signals. These findings point to new opportunities for more personalized treatment of this rare ovarian cancer.
Authors
- Samuel C. Mok (ORCID: https://orcid.org/0000-0001-7013-1805)
- Allison L. Brodsky (ORCID: https://orcid.org/0000-0002-9059-7888)
- Barrett C. Lawson (ORCID: https://orcid.org/0000-0003-2485-7087)
- Sammy Ferri‐Borgogno (ORCID: https://orcid.org/0000-0002-8270-8963)
- Veena K. Vuttaradhi (ORCID: https://orcid.org/0000-0002-3422-0509)
- R. Tyler Hillman (ORCID: https://orcid.org/0000-0002-9832-9925)
- Eleonora Khlebus (ORCID: https://orcid.org/0000-0002-8355-8960)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of California San Diego (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0333
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00