EP13.04 DEMOGRAPHIC, LOCATION, SIGN AND SYMPTOMS OF INTRACRANIAL MENINGIOMA AND ITS ASSOCIATION WITH TUMOR GRADE

Abstract BACKGROUND Epidemiologically, meningioma is the most common benign primary intracranial tumor. The tumor has been profoundly affect women compared to men. The majority of tumor located on cranial base. The symptoms of meningioma varied depends on the location of the tumor. Headache, seizure, and focal neurological deficits had variously reported before. Based on the WHO classification, there were benign meningioma (grade I) and non-benign meningioma (grade II-III). Although previous study suggest that benign meningioma has a predilection on the cranial base, the association between demographic, location, and sign and symptoms of meningioma with tumor grade remain uninvestigated. This study aims to investigate the association of demographic, location, sign and symptoms of meningioma with its tumor grade. MATERIAL AND METHODS This study is a cross sectional study of intracranial meningioma patients from 2013-2023 underwent surgery in Cipto Mangunkusumo General Hospital. Demographic, radiologic, and clinical data were retrieved from medical record. A chi-square analysis performed to determine the association of investigated variables with tumor grade. RESULTS There were 531 subjects acquired in this study of which the majority were female (92.1%). The median age of the subjects were 45(18-82) years old. Most of the subjects had tumor on cranial base (77.2%). Benign meningioma were found in the majority of subjects (89.6%). Gender (p=0.424), age (p=0.561), headache (p=0.176), sensory deficit (p=0.105), cranial nerve deficit (p=0.242), seizure (p=0.808), decreased consciousness (p=0.073) and hemianopia (p=0.377) were not associated with tumor grade. Meanwhile, convexity location (p=0.000) and motoric deficit (p=0.002) were associated with non-benign meningioma. CONCLUSION This study shows that convexity tumor is associated with non-benign meningioma. This finding is consistent with previous study findings. Motoric deficits also associated with non-benign meningioma. This could be explained by convexity tumor will affect motoric pathway more than on the cranial base. However, there are no association of gender and age with tumor grade found in this study although previous study showed otherwise. These findings remain to be investigated.