EP12.15 THE CORRELATION OF OBESITY AND INCIDENCE OF GLIOBLASTOMA WHO GRADE 4

Abstract BACKGROUND Glioblastoma (GBM) is the most common and aggressive primary brain neoplasia in adults. In recent years, a correlation of obesity and an incidence of tumors was shown for many solid cancers, including brain tumors. The present study aimed at determining the effects of lifestyle and dietary habits in the development of Glioblastoma WHO 4 and their effect in the overallsurvival after the operation. MATERIAL AND METHODS A retrospective review was performed for all patients with a histologically proven and first-diagnosed GBM between 2019 and 2023 in our department. Clinical and paraclinical parameters were acquired from patient documentation. Our study includes patients first diagnosed with primary GBM WHO Grade 4, IDH wildtype. Individuals with a secondary GBM or missing preoperative data were excluded. Data analysis of each patient included gender, age, BMI, Karnofsky performance score, tumor location and postoperative survival time. RESULTS In this study, 101 patients with a first diagnosed primary GBM were included (54 males, 47 females; mean age of 62.7 years, and range 33 to 82 years). All patients got a gross total resection. All of them received the standard adjuvant treatment according to Stupp et al. 52 Patients were overweight- Class I obesity, 18 patients had class II. Only 2 Patients were underweight and 29 patients had a normal weight. Ca. 69,3% of the patients with GBM were obese. Our study shows that there is an association between glioblastoma and overweight. Normal weight patients had a mean overall survival of 386.7, the obese patients had a mean OS of 463 days. 22 of the obese patients (from 70, ca. 31.4%) had an OS over mean OS (>463 days). This shows that the obesity does not impact the overallsurvival. CONCLUSION Our study finds an association of patient’s BMI with GBM’s incidence, but doesn’t show a relationship between BMI and OS.