MHC-mismatched synovial mesenchymal stem cell injections delay knee osteoarthritis progression through hepatocyte growth factor secretion in rats
Synovial MSCs derived from ACI rats effectively delayed OA progression in Lewis rats despite the full MHC mismatch. HGF secretion played a critical role in mediating these chondroprotective effects. These findings highlight HGF as a key therapeutic effector in MSC-based treatment of OA under immunologically mismatched allogeneic conditions.
Authors
- Ryo Kogawa (ORCID: https://orcid.org/0000-0001-8838-4376)
- Tsukasa Kitahashi (ORCID: https://orcid.org/0009-0003-5106-4776)
- Kentaro Nakamura (ORCID: https://orcid.org/0000-0001-5530-8051)
Institutions
- Fujifilm (Japan) (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1371/journal.pone.0333117
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujifilm Corporation