LRP5, a WNT signalling pathway receptor, and platelet activation
These findings reveal for the first time that LRP5 plays a critical role in platelet adhesion and thrombus formation. Genetic deletion and biochemical inhibition of LRP5 markedly impair platelet aggregation and thrombosis in preclinical models, without major effects on haemostasis. Although further research is needed to evaluate its clinical applicability, LRP5 appears as a novel and actionable target to modulate platelet reactivity and thrombosis.
Authors
- Lina Badimón (ORCID: https://orcid.org/0000-0002-9162-2459)
- María Borrell-Pagés (ORCID: https://orcid.org/0000-0002-1759-9756)
- Aureli Luquero (ORCID: https://orcid.org/0000-0002-1104-5963)
- Gemma Vilahur (ORCID: https://orcid.org/0000-0002-2828-8873)
- Noelia Pimentel (ORCID: https://orcid.org/0009-0009-1489-0861)
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Institute for Research in Biomedicine (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1093/eurheartj/ehaf772
- Citations
- 3
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 4.88