New partially silylated cyclodextrins with complex hydrogen bond networks

A series of partially silylated and unsymmetrical α-, β- and γ-cyclodextrins were prepared and the NMR spectra in CDCl₃ were analyzed. All unsymmetrical compounds showed a complex pattern of OH signals similarly to what has previously been seen for 6^A-F,2^A-hepta-O-tertbutyldimethylsilyl α-cyclodextrin. The compounds ability to form hydrogen bond network is discussed.