Feasibility of vinegar processing of toxic herbs in Shi–Zao–Tang: toxicity reduction, efficacy preservation in malignant ascites rats and underlying pharmacodynamic mechanisms
VSZT preserved the efficacy of SZT on MAE with lower intestinal toxicity. VSZT increased water excretion and decreased MAE formation to alleviate MAE through regulating gut microbiota, restoring tryptophan and tyrosine metabolism disorders, and affecting cAMP-PKA-CREB-AQP3 and VEGFA-VEGFR2-SRC-VE-cadherine pathway.
Authors
- Weifeng Yao (ORCID: https://orcid.org/0000-0002-6243-8548)
- Song-Lin Li
- Rongling Zhong
- Jin‐Di Xu
- Xiaoqin Gao (ORCID: https://orcid.org/0000-0001-5043-1122)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-6837-4258)
- Zhang Li (ORCID: https://orcid.org/0000-0001-7936-3864)
- Ting Geng (ORCID: https://orcid.org/0000-0002-0235-3112)
- Can Chen (ORCID: https://orcid.org/0000-0001-7096-1390)
- Jing Zhou (ORCID: https://orcid.org/0000-0002-4193-637X)
- Ting Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Provincial Academy of Traditional Chinese Medicine (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1186/s13020-025-01224-9
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province