Spatial transcriptomic profiling of metastatic renal cell carcinoma identifies chemokine-driven macrophage and CD8+ T-cell interactions predictive of immunotherapy response
Metastasis-specific immune niches, rather than primary-tumor characteristics, appear decisive for ICI efficacy in mRCC. Spatial transcriptomic profiling can identify these clinically relevant microenvironments and generate transferable gene signatures, supporting biomarker-driven patient selection and trial design. Integrating spatial TME analysis into future studies may accelerate personalized immunotherapy strategies for mRCC.
Authors
- Marcel Schwinger (ORCID: https://orcid.org/0009-0002-3267-6323)
- Charis Kalogirou (ORCID: https://orcid.org/0000-0003-3802-940X)
- Hubert Kübler (ORCID: https://orcid.org/0000-0002-6677-2519)
- Astrid Schmieder (ORCID: https://orcid.org/0000-0002-6421-9699)
- Oliver Hahn (ORCID: https://orcid.org/0000-0002-8864-2491)
- Andreas Steven Kunz (ORCID: https://orcid.org/0000-0001-8429-2992)
- Markus Krebs (ORCID: https://orcid.org/0000-0002-1154-0964)
- Markus Eckstein (ORCID: https://orcid.org/0000-0001-5418-3349)
- Arndt Hartmann
Institutions
- University of Augsburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Würzburg (DE)
- Universitätsklinikum Erlangen (DE)
- Augenklinik Universitätsklinikum Würzburg (DE)
- National Center for Tumor Diseases (DE)
- Universitätsklinikum Würzburg (DE)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012991
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81