Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency
Continuous wavelet analysis of these features demonstrates that scale-dependent, locus-specific factors influence the relationship between chromatin architecture and functional output, suggesting that regulation of transcription and nucleosome remodeling is not entirely (nor linearly) dependent upon large scale compartment exchange. Structural and functional responses are most pronounced early after treatment with partial persistence of differential local chromatin features and expression later in time; this highlights the plasticity of chromatin regulation, which may have implications for the efficacy of epigenetic treatments. These results demonstrate the effectiveness of multi-layered regulation of transcription: in resilient systems, disruption of one chromatin feature does not distort the regulation of other features in supporting a transcriptional program that allows for survival.
Authors
- Shawn R. Starkenburg (ORCID: https://orcid.org/0000-0002-8564-1274)
- Karissa Y. Sanbonmatsu (ORCID: https://orcid.org/0000-0002-7965-7392)
- Vrinda Venu (ORCID: https://orcid.org/0000-0001-6131-3340)
- Kyle A. Sullivan (ORCID: https://orcid.org/0000-0002-4621-5598)
- Daniel Jacobson (ORCID: https://orcid.org/0000-0002-9822-8251)
- Eric M. Small (ORCID: https://orcid.org/0000-0001-8593-0343)
- Samantha Adikari (ORCID: https://orcid.org/0000-0003-4515-5500)
- Anna Hendrika Cornelia Vlot (ORCID: https://orcid.org/0000-0001-9538-987X)
- Cullen Roth (ORCID: https://orcid.org/0000-0003-4934-6160)
- Christina Steadman (ORCID: https://orcid.org/0000-0002-9672-5529)
- Chanaka Roshan Abeyratne (ORCID: https://orcid.org/0000-0002-9561-3955)
Institutions
- Oak Ridge National Laboratory (US)
- Los Alamos National Laboratory (US)
- New Mexico Consortium (US)
- Los Alamos National Security (United States) (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s13072-025-00631-4
- Citations
- 2
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- U.S. Department of Energy
- Office of Science
- Biological and Environmental Research