Topiramate Enhances <scp>GABAergic</scp> Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide ( <scp>NPY</scp> / <scp>AgRP</scp> ) Neurons
This study is the first demonstration that topiramate strongly inhibits the activity of ARC NPY/AgRP neurons and suggests that enhanced GABAergic tone to these neurons mediates this effect. The ability of topiramate to inhibit the orexigenic NPY/AgRP neurons may underlie some of its weight-lowering properties.
Authors
- Olivier Lavoie (ORCID: https://orcid.org/0000-0002-0545-6993)
- Kevin W. Williams (ORCID: https://orcid.org/0000-0002-8434-8658)
- Natalie Jane Michael (ORCID: https://orcid.org/0000-0002-9032-0862)
- Moein Minbashi Moeini
- Alexandre Caron (ORCID: https://orcid.org/0000-0001-6939-6136)
Institutions
- Southwestern Medical Center (US)
- Lung Institute (US)
- Université Laval (CA)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Obesity
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1002/oby.70051
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canada Research Chairs
- Canada First Research Excellence Fund
- National Institutes of Health
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé