Supplementary Methods and Tables from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis

<p>Supplementary Methods and Tables: includes five sections. Section 1 outlines the comparison with previously published meta-analyses of mortality outcome surrogacy in cancer screening trials (including Table S1 and Table S2, and description of this work). Section 2 outlines the systematic searches in bibliographic databases and study selection (including Tables S3-S11 and description of this work). Section 3 provides detailed information on trials and the reported outcomes for the assessment of mortality outcome surrogacy (including Table S12-15, and a reference list for those four tables). Section 4 details the detailed meta-analytic results, including sensitivity and subgroup analyses (Including the methods that surround Figures S1-4, Table S16, Table S17). Section 5 includes selected aspects of limitations in the reported trial data (Table S19 and a description of this work).</p>

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Publication Details

Published
2025-10-03
DOI
https://doi.org/10.1158/1055-9965.30271514
Primary Topic
Health Systems, Economic Evaluations, Quality of Life
Type
article
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article

Supplementary Methods and Tables from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis

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Supplementary Methods and Tables from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis

Robert Allen Smith, Julia Geppert, Peter David Sasieni, Chris Stinton, Matejka Rebolj, Stephen William Duffy, Bethany Shinkins, Ruth Etzioni, Sam M. Janes, Samantha Johnson, Matthew J. Randell, Sian Taylor‐Phillips, Adam R. Brentnall, Karoline Freeman, Nefeli Kouppa
article en

Abstract

<p>Supplementary Methods and Tables: includes five sections. Section 1 outlines the comparison with previously published meta-analyses of mortality outcome surrogacy in cancer screening trials (including Table S1 and Table S2, and description of this work). Section 2 outlines the systematic searches in bibliographic databases and study selection (including Tables S3-S11 and description of this work). Section 3 provides detailed information on trials and the reported outcomes for the assessment of mortality outcome surrogacy (including Table S12-15, and a reference list for those four tables). Section 4 details the detailed meta-analytic results, including sensitivity and subgroup analyses (Including the methods that surround Figures S1-4, Table S16, Table S17). Section 5 includes selected aspects of limitations in the reported trial data (Table S19 and a description of this work).</p>

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