Abscopal effects in patients with malignant melanoma treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study
RT can induce AR in patients with MM with PD under ICI, particularly with hypofractionated regimens and long ICI-to-RT intervals. Our findings can serve as a reference for designing prospective trials.
Authors
- Ping Jiang (ORCID: https://orcid.org/0000-0002-7890-6713)
- Allison Lamrani (ORCID: https://orcid.org/0000-0002-4485-4900)
- Raphael Bodensohn (ORCID: https://orcid.org/0000-0002-1114-2771)
- Sally A. Elkhamisy (ORCID: https://orcid.org/0000-0002-3636-3829)
- Cindy Franklin (ORCID: https://orcid.org/0000-0001-9142-5423)
- Maike Trommer (ORCID: https://orcid.org/0000-0003-2864-4273)
- Matthias Mäurer (ORCID: https://orcid.org/0000-0001-9662-3082)
- Julian Philipp Layer (ORCID: https://orcid.org/0000-0001-7692-7775)
- Alexander Rühle (ORCID: https://orcid.org/0000-0003-2022-897X)
- Andrea Baehr (ORCID: https://orcid.org/0000-0003-0301-7249)
- Sebastian Neppl (ORCID: https://orcid.org/0000-0002-6095-6560)
- Simone Wegen (ORCID: https://orcid.org/0000-0002-0361-728X)
- Maria Waltenberger (ORCID: https://orcid.org/0000-0002-8064-0010)
- Danny Jazmati (ORCID: https://orcid.org/0000-0003-1600-9926)
- Anna Hagemeier (ORCID: https://orcid.org/0000-0002-8795-7352)
- Georg Wurschi (ORCID: https://orcid.org/0000-0002-8751-9862)
- Felix Ehret (ORCID: https://orcid.org/0000-0001-6177-1755)
- Davide Scafa
- Annika Hardt
- Charlotte Schmitter (ORCID: https://orcid.org/0000-0002-8666-3862)
- Justus Kaufmann (ORCID: https://orcid.org/0000-0003-0189-3499)
- Lukas Käsmann
- Esther G.C. Troost (ORCID: https://orcid.org/0000-0001-9550-9050)
Institutions
- Universität Hamburg (DE)
- University of Freiburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Johannes Gutenberg University Mainz (DE)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- Ospedale di Bolzano (IT)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Integrated Oncology (United States) (US)
- German Cancer Society (DE)
- Klinikum Lüdenscheid (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Children's Hospital Tübingen (DE)
- Jena University Hospital (DE)
- OncoRay (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University Hospital Cologne (DE)
- University Hospital Carl Gustav Carus (DE)
- Heinrich Heine University Düsseldorf (DE)
- Freie Universität Berlin (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012717
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05