Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis

Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis. However, the clinical relevance and how discordant biochemical and LSM changes should be best interpreted remain unclear. In this large international multicenter study, we demonstrated that once the current LSM is known, prior LSM trajectories and biochemical changes did not improve the prediction of liver-related events in patients with primary biliary cholangitis. Our finding addresses a common clinical dilemma in risk-stratifying PBC patients with discordant biochemical and LSM responses. Importantly, the use of the latest LSM value for risk prediction significantly simplifies the use of LSM in clinical decision-making for PBC patients with multiple LSM readings.

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Publication Details

Journal
Journal of Hepatology
Published
2025-10-03
DOI
https://doi.org/10.1016/j.jhep.2025.09.024
Citations
3
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
3.97

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article

Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis

Davide Roccarina, Douglas Thorburn, Eyal Yehezkel, Karsten Große et al.
3 citations
Journal of Hepatology
Liver Diseases and Immunity
3.97
article

Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis

Davide Roccarina, Douglas Thorburn, Eyal Yehezkel, Karsten Große, George Ν. Dalekos, Aldo J. Montaño‐Loza, John E. Eaton, Marcial Sebode, Vincenza Calvaruso, Aliya Gulamhusein, Tony Bruns, Francesco Paolo Russo, Christoph Schramm, Rozanne de Veer, Gideon M. Hirschfield, Cristina Rigamonti, Ignasi Olivas, Sara Lemoinne, Sergio Rodríguez‐Tajes, Pierre‐Antoine Soret, Ellina Lytvyak, Adèle Delamarre, Esli Medina‐Morales, Alessandra Zago, Natalia Sobenko, Adriaan van der Meer, Vilas R. Patwardhan, Nadir Abbas, Victor de Lédinghen, Annarosa Floreani, Georges‐Philippe Pageaux, Karim T. Osman, Olivier Chazouillères, Laurent Lam, Laura Cristoferi, Cynthia Levy, Nikolaos Gatselis, Atsushi Tanaka, Palak Trivedi, László Barkai, Pietro Invernizzi, Ansgar Wilhelm Lohse, Alan Bonder, Yu Jun Wong, Ansgar Deibel, Nora Cazzagon, Alejandra Villamil, Ehud Zigmond, Jessica Dyson, Frederik Nevens, Andreas Emanuel Kremer, Albert Parés, A. Fichera, Francesca Saffioti, Aaron Wetten, Christophe Corpechot, Jérôme Dumortier, Marco Carbone, David G. Jones, Fabrice Carrat, Maria-Carlota Londono, Bettina E. Hansen
article en
3 citations

Abstract

Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis. However, the clinical relevance and how discordant biochemical and LSM changes should be best interpreted remain unclear. In this large international multicenter study, we demonstrated that once the current LSM is known, prior LSM trajectories and biochemical changes did not improve the prediction of liver-related events in patients with primary biliary cholangitis. Our finding addresses a common clinical dilemma in risk-stratifying PBC patients with discordant biochemical and LSM responses. Importantly, the use of the latest LSM value for risk prediction significantly simplifies the use of LSM in clinical decision-making for PBC patients with multiple LSM readings.

Journal of HepatologyVol. 84(2)
Université Claude Bernard Lyon 1 (FR), Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT), National Health Service (GB), University Hospitals Birmingham NHS Foundation Trust (GB), Beth Israel Deaconess Medical Center (US), University Health Network (CA), Université de Bordeaux (FR), University of Alberta (CA), Inserm (FR), Universität Hamburg (DE), University of Toronto (CA), University of Zurich (CH), Santa Maria Nuova Hospital (IT), Tel Aviv Sourasky Medical Center (IL), The Royal Free Hospital (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Erasmus MC (NL), Hospital Italiano de Buenos Aires (AR), University of Alberta Hospital (CA), Sorbonne Université (FR), Centre Hospitalier Universitaire de Montpellier (FR), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Assistance Publique – Hôpitaux de Paris (FR), University Hospital of Zurich (CH), Hospices Civils de Lyon (FR), Hôpital Saint-Antoine (FR), University Hospital of Larissa (GR), University Medical Center Hamburg-Eppendorf (DE), Center for Digestive and Liver Diseases (US), Azienda Ospedaliera San Gerardo (IT), Mayo Clinic in Arizona (US), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES), Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR), Centre de Recherche Saint-Antoine (FR), Laboratoire National Henri Becquerel (FR), Oxford University Hospitals NHS Trust (GB), NIHR Birmingham Biomedical Research Centre (GB), ERN RARE-LIVER (DE), University College London (GB), University of Milano-Bicocca (IT), Universitat de Barcelona (ES), Miami University (US), Teikyo University (JP), RWTH Aachen University (DE), University of Palermo (IT), KU Leuven (BE)
Bristol-Myers Squibb, GlaxoSmithKline, Gilead Sciences, University of Miami, Wellcome Trust, LifeArc, Intercept Pharmaceuticals, National Institute for Health and Care Research, University College London, University of Oxford, Newcastle University, Università degli Studi di Milano-Bicocca, Università degli Studi di Padova, Newcastle upon Tyne Hospitals NHS Foundation Trust, Università degli Studi di Palermo, Genesis Pharma, Universitat de Barcelona, Oxford University Hospitals NHS Foundation Trust, Hospices Civils de Lyon, RWTH Aachen University, Ipsen, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Dr. Falk Pharma, Erasmus Universitair Medisch Centrum Rotterdam, Universitätsklinikum Hamburg-Eppendorf, Birmingham Biomedical Research Centre
Openalex Percentile: Top 5%
Liver Diseases and Immunity
3.97
DOIOpen Access PDFOpenAlex
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