CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion
T cell co-stimulation leading to activation is a central driver of the cardiac immune response following MI with reperfusion. The inhibition of this axis significantly protected against CIRI and preserved cardiac function. Ultimately, we highlight T cell immunomodulation and abatacept as highly promising approaches for clinical translation.
Authors
- Anna M.D. Watson (ORCID: https://orcid.org/0000-0001-5306-409X)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0001-8658-7399)
- Chad Johnson (ORCID: https://orcid.org/0000-0002-0017-4284)
- N. Dayawansa (ORCID: https://orcid.org/0000-0002-1863-092X)
- Anita C. Thomas (ORCID: https://orcid.org/0000-0002-3792-2653)
- Anne Nguyen (ORCID: https://orcid.org/0000-0001-5484-2578)
- Laura A. Bienvenu (ORCID: https://orcid.org/0000-0002-9216-076X)
- Karlheinz Peter (ORCID: https://orcid.org/0000-0002-8040-2258)
- D. Donner (ORCID: https://orcid.org/0000-0003-4924-720X)
- Prerna Sharma (ORCID: https://orcid.org/0009-0007-6878-7240)
- Yiyu Zhang (ORCID: https://orcid.org/0009-0008-4611-4704)
- Yuyang Song (ORCID: https://orcid.org/0000-0002-0973-2078)
- Marcel Michla
- Viktoria Bongcaron
- Angela Huang (ORCID: https://orcid.org/0009-0004-7054-4342)
- Jonathan Noonan (ORCID: https://orcid.org/0000-0001-9173-0903)
- Man K.S. Lee
- Andrew James Murphy (ORCID: https://orcid.org/0000-0001-7039-7777)
- James D. McFadyen (ORCID: https://orcid.org/0000-0002-9832-6871)
- Anastasia Barbaro-Wahl (ORCID: https://orcid.org/0009-0001-1058-7824)
- Shania A Prijaya
- Thanh Nguyen (ORCID: https://orcid.org/0000-0001-8378-555X)
- Yilu Huang
Institutions
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- La Trobe University (AU)
- The Alfred Hospital (AU)
- Melbourne Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1093/cvr/cvaf165
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00