Proteomic landscape of porcine induced neural stem cell reprogramming and differentiation
This study provides the first comprehensive proteomic map of piNSC reprogramming and differentiation in a large animal model. Our findings uncover critical regulatory proteins and pathways governing cytoskeletal organization, metabolism, and RNA processing, offering valuable insights into neural fate states. This resource advances the understanding of neural reprogramming in translational models and supports future regenerative and comparative neuroscience efforts.
Authors
- Somjit Chaiwattanarungruengpaisan (ORCID: https://orcid.org/0000-0002-0705-9131)
- Nattarun Chaisilp (ORCID: https://orcid.org/0009-0009-6896-4467)
- Sasitorn Rungarunlert (ORCID: https://orcid.org/0000-0001-5500-1295)
- Sekkarin Ploypetch (ORCID: https://orcid.org/0000-0003-4985-2565)
- Supitcha Pannengpetch
- Piyada Na Nakorn (ORCID: https://orcid.org/0009-0000-0946-2445)
- Sataporn Phochantachinda (ORCID: https://orcid.org/0000-0003-2746-5353)
- Warunya Chakritbudsabong (ORCID: https://orcid.org/0009-0004-8502-8615)
- Walasinee Sakcamduang (ORCID: https://orcid.org/0000-0002-8245-9506)
- Tharathip Muangthong
Institutions
- Mahidol University (TH)
Publication Details
- Journal
- PeerJ
- Published
- 2025-10-03
- DOI
- https://doi.org/10.7717/peerj.20120
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00