Acetaminophen aggravates valproate‐induced hepatic lipid accumulation and apoptosis by facilitating valproate retention
VPA is the main factor contributing to intrahepatic lipid accumulation, but did not induce apoptosis of hepatocytes. APAP inhibited β-oxidation of VPA and caused VPA retention, which aggravated and prolonged the lipid accumulation and finally resulted in hepatocyte apoptosis. We provide evidence and guidance on the use of VPA and APAP in the clinic.
Authors
- Zhenzhou Jiang (ORCID: https://orcid.org/0000-0002-0420-0822)
- Luyong Zhang (ORCID: https://orcid.org/0000-0003-1164-7371)
- Lixia Pang
- Anqin Li (ORCID: https://orcid.org/0000-0001-6434-9488)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7905-034X)
- Xiaoyun Liu (ORCID: https://orcid.org/0000-0002-5483-0742)
- Shusheng Fan
- Jingwen Li (ORCID: https://orcid.org/0009-0000-3382-6341)
Institutions
- China Pharmaceutical University (CN)
- Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1111/bph.70214
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00