Direct Boron‐10 Access: Nickel‐Catalyzed Reductive C(sp <sup>2</sup> )─ <sup>10</sup> B Coupling Utilizing <sup>10</sup> BF <sub>3</sub>
The boron-10 isotope (<sup>10</sup>B) is critical for boron neutron capture therapy (BNCT); however, the direct use of industrially available <sup>10</sup>BF<sub>3</sub> for synthesizing <sup>10</sup>B-enriched compounds remains challenging due to the strong B─F bonds. Herein, we present a nickel-catalyzed reductive protocol that enables direct C(sp<sup>2</sup>)─<sup>10</sup>B bond formation using <sup>10</sup>BF<sub>3</sub>. This approach employs AlCl<sub>3</sub> and a Lewis base to generate electrophilic borenium ions in situ. The method eliminates the need for pre-functionalized boron reagents, providing an efficient route to diverse <sup>10</sup>B-enriched compounds with promising applications in BNCT and neutron-shielding materials.
Authors
- Shuai Liu (ORCID: https://orcid.org/0000-0002-4624-6458)
- Xiang‐Yu Chen (ORCID: https://orcid.org/0000-0002-0383-0910)
- Bei‐Bei Zhang
- Qiang Liu (ORCID: https://orcid.org/0000-0001-8845-1874)
- Zhixiang Wang (ORCID: https://orcid.org/0000-0001-5815-3032)
- Chun‐Fu Meng
Institutions
- Binzhou People's Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1002/anie.202513304
- Citations
- 3
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 4.08