MNDA promotes immunosuppression in microsatellite instability-high colorectal cancer by facilitating PMN-MDSC infiltration via H3K18 lactylation
Our study reveals a novel mechanism by which MNDA-driven H3K18 lactylation of the CXCR2 promoter facilitates immune evasion and PD-1 resistance in MSI-H CRC. Targeting the MNDA/EP300-CXCR2 regulatory axis represents a promising strategy for overcoming ICI resistance and enhancing the therapeutic benefit in CRC.
Authors
- Jibiao Li (ORCID: https://orcid.org/0000-0002-1948-6675)
- Qing Feng (ORCID: https://orcid.org/0000-0001-5245-6710)
- Xiao-qiong Chen
- Wei Xiong (ORCID: https://orcid.org/0000-0003-1635-8173)
- Xinyi Cai (ORCID: https://orcid.org/0000-0002-4444-4231)
- Quan Yang (ORCID: https://orcid.org/0000-0003-4324-5895)
- Xuan Zhang (ORCID: https://orcid.org/0009-0008-6030-0570)
- Tao Wu (ORCID: https://orcid.org/0009-0007-7864-6695)
- Wenbin Wang
Institutions
- Chongqing University (CN)
- Kunming Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12967-025-07097-8
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Kunming Medical University