Maternal glucose concentrations and DNA methylation of genes related to the PPAR signaling pathway in human placenta: insights for maternal glucose concentrations’ effects on neonatal anthropometrics
Elevated Maternal glucose concentrations were associated with hypomethylation of genes related to the PPAR signaling pathway. Specifically, hypomethylation of ACAA1 and ACADM may partially mediate the impact of maternal glucose concentrations on increased neonatal anthropometric measures. These findings provide mechanistic insights into potential epigenetic pathways linking maternal glucose concentrations to neonatal anthropometric outcomes.
Authors
- Likang Li
- Lei Zhang (ORCID: https://orcid.org/0000-0002-0580-0889)
- Honglei Ji (ORCID: https://orcid.org/0009-0009-9053-5220)
- Hong Liang (ORCID: https://orcid.org/0000-0001-6131-7181)
- Wei Yuan (ORCID: https://orcid.org/0000-0002-1122-6481)
- Xiuxia Song
- Min Luan
- Fen Yang (ORCID: https://orcid.org/0000-0001-6050-9448)
- Yafei Chen (ORCID: https://orcid.org/0000-0002-5177-0772)
- Maohua Miao
Institutions
- Fudan University (CN)
- Chinese National Human Genome Center (CN)
- Karolinska Institutet (SE)
- Minhang District Central Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s13148-025-01974-1
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China