O035 Sleep status informs exercise prescription in hip osteoarthritis

Abstract Introduction Exercise is a core treatment for hip osteoarthritis (OA). However, effects vary and are on average modest at best. This may be explained by different exercise types having different effects depending on individual characteristics. We tested this theory. Methods 185 participants with hip OA were randomized to receive one of two 12-week exercise interventions: (1) combined aerobic and resistance or (2) resistance only. Hierarchical clustering was performed on baseline measures of BMI, pain, function, sleep duration and quality, fatigue, gait self-efficacy, anxiety, depression, stress, and fear of movement. After clustering, ANOVAs determined which variables differentiated the clusters. Repeated mixed-effects models explored whether patient specific function responded differently depending on the cluster and intervention type. Results Clustering identified four clusters with distinct characteristics termed: “high pain, low function & psychological distress” (Cluster 1), “high pain & low function” (Cluster 2), “poor sleep” (Cluster 3), and “low pain & high functioning” (Cluster 4). Post-intervention function improved in response to both interventions in all clusters (p<.05) except for Cluster 3 (poor sleep), which improved only with combined aerobic/resistance exercise (p<.001). Although Cluster 2 improved with both interventions, least improvement occurred with resistance exercise – with post-intervention function lower relative to individuals from all other clusters who performed combined aerobic/resistance exercise (p<.05). Discussion Individuals with hip OA who present with poor sleep as the primary symptom may benefit most from combined aerobic/resistance but not resistance alone exercise. Studies that tease out the full benefits of either intervention for these subgroups are needed.