Effect of tumor draining lymph nodes in the formation and maturation of tertiary lymphoid structure in patients with lung adenocarcinoma
This study demonstrated that B cells in the tumor and TDLN play critical roles in the formation and maturation of TLS. TIM-1 + B cell is a unique immunosuppressive B cell subset that impedes the maturation of TLS and could be a promising target for improving the maturation of TLS and the prognosis of LUAD.
Authors
- Xiaoyan Yin (ORCID: https://orcid.org/0000-0002-2141-3934)
- Wenhua Yun
- Jun Wen (ORCID: https://orcid.org/0000-0003-2929-1270)
- Xiangjiao Meng
Institutions
- Shandong Tumor Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12885-025-14913-3
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province