Role of Glyoxalase in Astrocytes’ Supportive Function Under Hyperglycemic Conditions: Aminoguanidine and Kir4.1 Channel Recovery
We demonstrated that regulation of the glyoxalase system via AG or another scavenger of carbonyl and aldehydes containing polyamine groups can contribute to the recovery of astrocyte function in diabetic patients.
Authors
- Jadier Colón‐Vázquez (ORCID: https://orcid.org/0000-0003-3859-9680)
- Serguei N. Skatchkov (ORCID: https://orcid.org/0000-0002-3698-2419)
- Misty J. Eaton (ORCID: https://orcid.org/0000-0001-5968-5727)
- David E. Rivera-Aponte
- Miguel P. Méndez-González (ORCID: https://orcid.org/0000-0003-0079-4042)
- Gerónimo Maldonado-Martínez (ORCID: https://orcid.org/0000-0002-6859-0866)
- Nathaly M. Rosado-Rivera
- Joshua J. Navedo-Jackson
- Arelys A. Angueira-Laureano
- Yanitza Hernandez-Santiago
Institutions
- Universidad Complutense de Madrid (ES)
- University of Puerto Rico, Medical Sciences Campus (PR)
- University of Puerto Rico System (PR)
- Central University of the Caribbean (PR)
- University of Puerto Rico at Aguadilla (PR)
- Antillean Adventist University (PR)
- University of Puerto Rico at Bayamón (PR)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3390/brainsci15101075
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- American Diabetes Association
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- National Institute on Minority Health and Health Disparities