RNA interference medication and transplantation procedures in patients with primary hyperoxaluria type 1
Pox should not be the sole parameter to decide on Tx procedure. In patients with minor oxalate deposition, no SOG deterioration and sensitivity to vitamin B6 or under efficacious RNAi treatment, iKTx can be considered. Severe (and deteriorating) systemic oxalosis, high Pox during RNAi treatment and maximum dialysis, makes us reconsider combined or sequential LKTx rather than iKTx. Patients with severe systemic oxalosis at time of diagnosis still have a high mortality rate.
Authors
- Caroline Kempf (ORCID: https://orcid.org/0000-0002-9462-3158)
- Lodovica Borghese
- Mark Born (ORCID: https://orcid.org/0000-0002-1740-0006)
- Britta Höcker (ORCID: https://orcid.org/0000-0003-4131-2273)
- Adam Walli (ORCID: https://orcid.org/0009-0001-8834-6414)
- Katharina Linden (ORCID: https://orcid.org/0000-0003-2075-2675)
- Bernd Höppe (ORCID: https://orcid.org/0000-0002-8120-3306)
- Jens König (ORCID: https://orcid.org/0000-0002-9732-8656)
- Cristina Martín-Higueras (ORCID: https://orcid.org/0000-0003-1139-4642)
- Henry Fehrenbach
Institutions
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Hospital Heidelberg (DE)
- University Hospital Münster (DE)
- Laboratory Dr. Wisplinghoff (DE)
- Oxalosis and Hyperoxaluria Foundation (US)
- Universitätsklinikum Aachen (DE)
- Sana Klinikum Offenbach (DE)
- Kernkraftwerk Gundremmingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/ndt/gfaf202
- Citations
- 2
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04