Mediterranean diet, metabolic signature, genetic predisposition, and risk of rheumatoid arthritis: a large-scale population-based prospective cohort study
We identified a robust metabolic signature reflecting the metabolic response to the MED diet. This signature was inversely associated with RA risk and partially mitigated the genetic susceptibility to RA. These findings highlight the potential of metabolic signatures for enhancing dietary assessment and guiding personalized nutritional intervention.
Authors
- Tao Han (ORCID: https://orcid.org/0000-0003-3814-8492)
- Karin Leander (ORCID: https://orcid.org/0000-0002-1404-9222)
- Sirui Zheng
- Rong Xiang (ORCID: https://orcid.org/0000-0003-3487-7348)
- Bin Yang (ORCID: https://orcid.org/0000-0002-7155-6079)
- Mengyu Fan (ORCID: https://orcid.org/0000-0002-6452-3383)
- Xunying Zhao (ORCID: https://orcid.org/0000-0002-6754-9773)
- Xiaofeng Ma (ORCID: https://orcid.org/0000-0003-3725-1391)
- Yang Qu (ORCID: https://orcid.org/0000-0002-6173-8100)
- Jinyu Zhou (ORCID: https://orcid.org/0000-0002-5406-5227)
- Xia Jiang (ORCID: https://orcid.org/0000-0003-0349-8126)
- Lars S. Alfredsson (ORCID: https://orcid.org/0000-0003-1688-6697)
- Mingzhu Xia (ORCID: https://orcid.org/0000-0001-7533-6535)
- Yong Zhong (ORCID: https://orcid.org/0000-0002-7450-1794)
- Yanqiu Zou
- Ting Yu (ORCID: https://orcid.org/0000-0003-4096-8975)
- Xin Song (ORCID: https://orcid.org/0009-0004-8767-467X)
- Di Zhang (ORCID: https://orcid.org/0000-0002-4130-0769)
- Bowen Lei
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- Karolinska Institutet (SE)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.09.051
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06