Bilateral and recurrent adrenocortical carcinoma in MEN1: a case report and review of the literature
MEN1 is associated with an increased incidence of both benign and malignant adrenal lesions.The incidence of ACC among patients with MEN1 is between 0.5 and 6.9%, with a female predisposition.Bilateral ACC is rare in patients with MEN1 and in the wider ACC population.Positron emission tomography (PET) scanning using molecular tracers that bind to steroidogenic enzymes can identify whether lesions are adrenocortical in origin and has an emerging role in the diagnosis of indeterminate adrenal lesions, particularly in the presence of other primary cancers.
Authors
- Inês Harper
- Benjamin Challis (ORCID: https://orcid.org/0000-0002-1130-2851)
- James MacFarlane (ORCID: https://orcid.org/0000-0001-6937-2775)
- Joo Ern Ang (ORCID: https://orcid.org/0000-0003-2103-996X)
- Victoria Stokes (ORCID: https://orcid.org/0000-0002-9000-0834)
- Ruth Therese Casey (ORCID: https://orcid.org/0000-0003-4058-3135)
- Sophie Howarth (ORCID: https://orcid.org/0000-0001-7169-2356)
- August Palma
- Mark Gurnell (ORCID: https://orcid.org/0000-0001-5745-6832)
- John A. Tadross (ORCID: https://orcid.org/0000-0002-8424-1252)
- Ashley Shaw
- Heok Cheow (ORCID: https://orcid.org/0009-0001-4860-8766)
Institutions
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Endocrine Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1530/eo-25-0067
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00