Tiotropium in Patients With Airflow Limitation According to the Fixed Ratio But Not the Lower Limit of Normal: A Secondary Analysis of the Tie-COPD Study
This study demonstrated tiotropium treatment improved lung function, ameliorated lung function decline, and reduced exacerbations compared with placebo in patients with FR+LLN-, providing evidence-based medicine support for the treatment in this population.
Authors
- Kunning Zhou (ORCID: https://orcid.org/0000-0002-2805-9317)
- Huang Su-ying
- Fan Wu (ORCID: https://orcid.org/0000-0003-1414-9896)
- Yumin Zhou
- Nanshan Zhong (ORCID: https://orcid.org/0000-0003-2274-1427)
- Zhishan Deng (ORCID: https://orcid.org/0009-0001-3836-7583)
- Qing Wan (ORCID: https://orcid.org/0009-0006-6348-7006)
- Pixin Ran (ORCID: https://orcid.org/0000-0003-2221-8986)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.15326/jcopdf.2025.0629
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- COPD Foundation
- Guangzhou Medical University
- State Key Laboratory of Respiratory Disease
- Sun Yat-sen University
- Fudan University
- Huazhong University of Science and Technology
- Jinan University
- Tongji University
- Shanghai Xuhui District Central Hospital
- Henan Provincial People's Hospital