Characteristics associated with breakthrough congenital syphilis in Florida and Arizona, 2018-2022

Congenital syphilis (CS) can occur despite timely identification and adequate treatment of maternal syphilis (breakthrough CS). We examined associations between maternal characteristics and prevalence of breakthrough CS. Having primary/secondary syphilis, a higher maximum non-treponemal titer, and treatment initiation closer to delivery were associated with higher prevalence of breakthrough CS.

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Publication Details

Journal
Sexually Transmitted Diseases
Published
2025-10-03
DOI
https://doi.org/10.1097/olq.0000000000002249
Primary Topic
Syphilis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Characteristics associated with breakthrough congenital syphilis in Florida and Arizona, 2018-2022

Breanne Anderson, James Matthias, Nicole L. Davis, Felicia M. T. Lewis et al.
Sexually Transmitted Diseases
Syphilis Diagnosis and Treatment
article

Characteristics associated with breakthrough congenital syphilis in Florida and Arizona, 2018-2022

Breanne Anderson, James Matthias, Nicole L. Davis, Felicia M. T. Lewis, Joshua Lassen, Maegan Matter
article en

Abstract

Congenital syphilis (CS) can occur despite timely identification and adequate treatment of maternal syphilis (breakthrough CS). We examined associations between maternal characteristics and prevalence of breakthrough CS. Having primary/secondary syphilis, a higher maximum non-treponemal titer, and treatment initiation closer to delivery were associated with higher prevalence of breakthrough CS.

Sexually Transmitted Diseases
Centers for Disease Control and Prevention (US), Arizona Department of Health Services (US), Florida Department of Health (US)
Openalex Percentile: Top 66%
Syphilis Diagnosis and Treatment
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Characteristics associated with breakthrough congenital syphilis in Florida and Arizona, 2018-2022 — Breanne Anderson, James Matthias, et al. · Sexually Transmitted Diseases (2025) | TGRS Research Map | TGRS