FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia
Activation of the CMTM6/PD-L1 axis in FLT3-ITD-driven acute myeloid leukemia mediates immunosuppression, providing the basis for potential inhibition of this pathway to harness antitumor immunity.
Authors
- Heidi Altmann (ORCID: https://orcid.org/0000-0003-1967-0330)
- Alexandra Emilia Schlaak (ORCID: https://orcid.org/0000-0001-5892-9224)
- Johannes Schetelig (ORCID: https://orcid.org/0000-0002-2780-2981)
- Tamina Rückert (ORCID: https://orcid.org/0000-0003-0723-8110)
- Melanie Boerries (ORCID: https://orcid.org/0000-0002-3670-0602)
- Melissa Zwick (ORCID: https://orcid.org/0009-0000-1482-2062)
- Natalie Köhler (ORCID: https://orcid.org/0000-0002-7502-0431)
- M. Angel (ORCID: https://orcid.org/0009-0003-5644-0515)
- Sandra Kissel
- Justus Duyster (ORCID: https://orcid.org/0009-0003-1497-3954)
- Anna-Lena Illert (ORCID: https://orcid.org/0000-0003-3141-417X)
- Lukas M. Braun (ORCID: https://orcid.org/0000-0003-0770-4994)
- Bertram Bengsch (ORCID: https://orcid.org/0000-0003-2552-740X)
- Annika Nelde (ORCID: https://orcid.org/0000-0001-8504-8481)
- Severin Dicks (ORCID: https://orcid.org/0000-0002-0370-1983)
- Sandra Duquesne (ORCID: https://orcid.org/0000-0002-9133-6065)
- Abhijeet Todkar (ORCID: https://orcid.org/0000-0002-8699-0425)
- Corinna Spohr (ORCID: https://orcid.org/0000-0002-9781-4443)
- Tilman Brummer (ORCID: https://orcid.org/0000-0003-4387-7905)
- Sebastian Halbach (ORCID: https://orcid.org/0000-0002-6827-8178)
- Samuel J. Holzmayer (ORCID: https://orcid.org/0009-0006-4513-2367)
- Anna-Sophia Baur
- Marie Follo (ORCID: https://orcid.org/0000-0002-3090-7442)
- Patricia Otto-Mora
- Desireé Kunadt (ORCID: https://orcid.org/0000-0001-8750-5308)
- Gerd Walz (ORCID: https://orcid.org/0000-0002-4950-9946)
- Khalid Shoumariyeh (ORCID: https://orcid.org/0000-0001-7969-1972)
- Jonas Scheid (ORCID: https://orcid.org/0000-0002-5923-1343)
- Marcel Schiff (ORCID: https://orcid.org/0000-0003-3408-0064)
- Robert Zeiser (ORCID: https://orcid.org/0000-0001-6565-3393)
- Juliane S. Walz (ORCID: https://orcid.org/0000-0001-6404-7391)
- Melanie Märklin (ORCID: https://orcid.org/0000-0002-2920-3894)
- Michael Selle (ORCID: https://orcid.org/0000-0003-3664-6826)
- Bastian Zinkel (ORCID: https://orcid.org/0009-0000-0239-7505)
- Elisa Michaeli
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- TUM Klinikum (DE)
- Universitätsklinikum Tübingen (DE)
- University Children's Hospital Tübingen (DE)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- University Hospital Carl Gustav Carus (DE)
- Deutsche Knochenmarkspenderdatei (DE)
- Technical University of Munich (DE)
- Technische Universität Dresden (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0349
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00