Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive Impairment
These results support the potential utility of PRS for plasma t-tau in predicting AD/aMCI incidence. The relationship between genetic predisposition for elevated plasma t-tau levels and AD pathology might be influenced by sex and age, suggesting that these factors should be considered in AD genetic risk modeling. PRS could serve as an early indicator of genetic propensity for tau pathology, enhancing existing AD diagnostic and risk stratification algorithms.
Authors
- Georgios M. Hadjigeorgiou (ORCID: https://orcid.org/0000-0001-5386-4273)
- Efthimios Dardiotis (ORCID: https://orcid.org/0000-0003-2957-641X)
- Niki Mourtzi (ORCID: https://orcid.org/0000-0002-8650-4239)
- Alexandros Hatzimanolis (ORCID: https://orcid.org/0000-0002-0291-1399)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Christopher Papandreou (ORCID: https://orcid.org/0000-0002-6803-507X)
- Eva Ntanasi (ORCID: https://orcid.org/0000-0001-9311-0994)
- Mary Yannakoulia (ORCID: https://orcid.org/0000-0003-2171-7337)
- Marios K. Georgakis (ORCID: https://orcid.org/0000-0003-3507-3659)
- Mary H. Kosmidis (ORCID: https://orcid.org/0000-0001-8790-1220)
- Eirini Mamalaki (ORCID: https://orcid.org/0000-0002-5714-3032)
- Sokratis Charisis (ORCID: https://orcid.org/0000-0001-6578-393X)
- Nikolaos Scarmeas (ORCID: https://orcid.org/0000-0001-6453-8908)
- Stefanos N. Sampatakakis (ORCID: https://orcid.org/0009-0009-7316-0471)
- Paraskevi Sakka
Institutions
- Broad Institute (US)
- University of Thessaly (GR)
- University of Nicosia (CY)
- University of Cologne (DE)
- Aristotle University of Thessaloniki (GR)
- Mediterranean University (ME)
- German Center for Neurodegenerative Diseases (DE)
- Harokopio University of Athens (GR)
- Massachusetts General Hospital (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University Hospital of Larissa (GR)
- Institute for Neurodegenerative Disorders (US)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Eginition Hospital (GR)
- Hospital Universitari Sant Joan de Reus (ES)
- Greek Association of Alzheimer's Disease and Related Disorders (GR)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neurology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1212/wnl.0000000000213904
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00