Critical commentary on: “Effect of Levothyroxine on Miscarriage among Women with Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial”.

This is a critical commentary about an RCT known as the Euthyroid Women with Thyroid Autoimmunity after Levothyroxine (POSTAL) study. Using the Trustworthiness in Randomised Clinical Trials (TRACT) checklist, five concerns in 5 domains out of 7 were identified. Four concerns are considered major due to retrospective registration, significance and inconsistencies in summary data presented, fast recruitment of patients and major discrepancies in data as well as methodology that exist between the conference abstract and the published trail. These serious and multiple concerns suggest the urgent need for reliable investigation of the trustworthiness of the POSTAL study. The authors of the POSTAL study are encouraged to share their original data set on a public domain.