Comprehensive Molecular Studies in 88 Japanese Patients With Congenital Hypogonadotropic Hypogonadism
The results support the notion that CHH occurs not only as a monogenic disorder but also as an oligogenic/multifactorial disorder, and suggest the involvement of ZNF462, SEMA4D, and CDH2 variants in the development of CHH.
Authors
- Tsutomu Ogata (ORCID: https://orcid.org/0000-0001-7178-9991)
- Kaori Yamoto (ORCID: https://orcid.org/0000-0001-6001-6395)
- Tadashi Kaname (ORCID: https://orcid.org/0000-0003-0281-9610)
- Yohei Masunaga (ORCID: https://orcid.org/0000-0002-4910-8640)
- Yasuko Fujisawa (ORCID: https://orcid.org/0000-0002-6560-4214)
- Wataru Tanikawa (ORCID: https://orcid.org/0000-0002-3083-0959)
- Itaru Ohyama
- Osamu Ohara (ORCID: https://orcid.org/0000-0002-3328-9571)
- Maki Fukami (ORCID: https://orcid.org/0000-0001-9971-4035)
- Hirotomo Saitsu (ORCID: https://orcid.org/0000-0003-0723-0960)
- Shingo Okamoto
Institutions
- Hamamatsu University School of Medicine (JP)
- Akebono Clinic (JP)
- National Center For Child Health and Development (JP)
- Kazusa DNA Research Institute (JP)
- Hamamatsu Medical Center (JP)
- Wakamoto Pharmaceutical (Japan) (JP)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1210/clinem/dgaf548
- Citations
- 1
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 1.70