Regulatory Roles of IGF2R in Insulin Secretion and Adaptive β-Cell Proliferation
The significance of insulin-like growth factor-2 receptor (IGF2R) in β-cells remains unclear. To assess the physiological role of IGF2R in β-cells, the effects of IGF2R deficiency in vivo and in vitro were investigated. IGF2R modulates insulin secretion, cell proliferation, and autophagy in β-cells. IGF2R plays a role in the regulation of β-cell biology.
Authors
- Takahiro Tsuno (ORCID: https://orcid.org/0000-0002-5463-4493)
- Tomozumi Takatani
- Giorgio Basile (ORCID: https://orcid.org/0000-0001-9900-4922)
- Rohit Kulkarni (ORCID: https://orcid.org/0000-0001-5029-6119)
- Erin R. Okawa (ORCID: https://orcid.org/0000-0001-8407-5250)
- Tomohiko Tamura
- Akira Nishiyama (ORCID: https://orcid.org/0000-0002-8802-3770)
- Jun Shirakawa (ORCID: https://orcid.org/0000-0002-0822-8750)
- Dario F. De Jesus (ORCID: https://orcid.org/0000-0001-8826-9095)
- Yasuo Terauchi (ORCID: https://orcid.org/0000-0002-8872-3697)
- Ryota Inoue (ORCID: https://orcid.org/0009-0002-5573-5920)
Institutions
- Joslin Diabetes Center (US)
- Beth Israel Deaconess Medical Center (US)
- Gunma University (JP)
- Yokohama City University Medical Center (JP)
- University of Chicago (US)
- Dokkyo Medical University Saitama Medical Center (JP)
- Harvard Stem Cell Institute (US)
- Yokohama City University (JP)
Publication Details
- Journal
- Diabetes
- Published
- 2025-10-03
- DOI
- https://doi.org/10.2337/db25-0215
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01