Checkpoint Imbalance in Primary Glomerulopathies: Comparative Insights into IgA Nephropathy and Membranoproliferative Glomerulonephritis
IgAN and MPGN share a sex-independent checkpoint signature: PD-1/PD-L1 and CD200R/CD200 upregulation with CTLA-4/CD86 downregulation. CD19<sup>+</sup>, CTLA-4<sup>+</sup>, and soluble PD-1/PD-L1/CD200(R) emerge as promising biomarkers requiring further validation.
Authors
- Iwona Smarz-Widelska
- Wojciech Załuska (ORCID: https://orcid.org/0000-0001-6043-3236)
- Ewelina Grywalska (ORCID: https://orcid.org/0000-0002-0451-4741)
- Sebastian Mertowski (ORCID: https://orcid.org/0000-0002-7121-1396)
- Paulina Mertowska (ORCID: https://orcid.org/0000-0001-9530-6659)
- Milena Czosnek
Institutions
- Medical University of Lublin (PL)
Publication Details
- Journal
- Cells
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3390/cells14191551
- Citations
- 2
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 2.86