Comparison of 2 Doses vs 1 Dose in the First Season Children Are Vaccinated Against Influenza
In this systematic review and meta-analysis of influenza vaccine efficacy and effectiveness in the first year of vaccination, receiving 2 doses of inactivated influenza vaccine was associated with improved protection for children younger than 3 years compared with those who receive one dose; however, when the age range was broadened to younger than 9 years, the second dose of inactivated influenza vaccine was not significantly associated with increased protection. Additional high-quality studies are needed to assess the impact of the 2-dose schedule for both vaccine types by age to determine the age range for which a 2-dose schedule is beneficial.
Authors
- Annette K. Regan (ORCID: https://orcid.org/0000-0002-3879-6193)
- Sheena G. Sullivan (ORCID: https://orcid.org/0000-0002-0856-0294)
- Patricia T. Campbell (ORCID: https://orcid.org/0000-0003-4013-9835)
- Jessie J. Goldsmith (ORCID: https://orcid.org/0000-0003-4970-7843)
- Sarah Tavlian (ORCID: https://orcid.org/0009-0007-2502-3056)
- Christy Vu (ORCID: https://orcid.org/0000-0002-4838-167X)
Institutions
- The Royal Melbourne Hospital (AU)
- Kaiser Permanente (US)
- University of California, Los Angeles (US)
- The University of Melbourne (AU)
- Peter Doherty Institute (AU)
- Monash University (AU)
- University of San Francisco (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.35250
- Citations
- 3
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Veski
- Australian Government
- Department of Health and Aged Care, Australian Government