Metabolic Shift Mirrors GBM Immunity to Anti-PD-L1 Immunotherapy: A Deuterium MRS Study
A metabolic program skewed toward oxidative phosphorylation and away from glycolysis has been associated with immune dysfunction. This study documents such a skewed metabolic state in ICB refractory GL261 GBM growing in irradiated brain (tumors were not irradiated) compared to control brain.
Authors
- Keith M. Rich (ORCID: https://orcid.org/0000-0001-5593-5098)
- Joseph J. H. Ackerman (ORCID: https://orcid.org/0000-0002-6514-9282)
- John A. Engelbach
- Joel R. Garbow (ORCID: https://orcid.org/0000-0002-0654-2703)
- Tanner M. Johanns (ORCID: https://orcid.org/0000-0003-1094-1528)
- Xia Ge
Institutions
- Washington University in St. Louis (US)
- Jewish Hospital (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1007/s11307-025-02037-w
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Barnes-Jewish Hospital
- Alvin J. Siteman Cancer Center
- National Institutes of Health