Experimental resininfiltrant with antibacterialactivity and ionic release

Objective: To assess the influence of the combination of the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM) and amorphous calcium phosphate nanoparticles (NACP) on the antibacterial and ion release potentials, as well as the physical properties of experimental resin infiltrants. Methodology: The study comprised the following groups: ERI (Pure Experimental Resin Infiltrant [ERI]: 75% TEGDMA + 25% BisEMA, 0.5% camphorquinone [CQ], and 1% ethyl 4-dimethylaminobenzoate [EDMAB]); ERIDM (ERI + 3% DMAHDM), ERINACP (ERI + 1.5% NACP), and ERIDM_NACP (ERI + 3% DMAHDM + 1.5% NACP). From samples of each group, Degree of Conversion (DC; n=6) and Sorption and Solubility (SO/SOL; n=8) were assessed. The antibacterial potential was evaluated through biomass accumulation (BA; n=6) and bacterial metabolism (BM; n=6) assays after cultivating Streptococcus mutans biofilm on the materials. Ionic release (IR; n=3) of Ca2+ and PO4 (3-) from the groups after 7, 14, and 28 days of immersion was also analyzed. Data were analyzed for normality and homoscedasticity, and statistical analysis was performed using appropriate tests with a significance level of 5%. Results: For DC, ERIDM showed no statistical difference from ERI. ERI had the lowest means of SO/SOL, and ERIDM_NACP had the highest. ERIDM exhibited no statistical difference from ERI. For BM, ERIDM and ERIDM_ NACP had the lowest means. ERINACP and ERIDM_NACP exhibited ionic release during the analyzed period. Conclusions: The resin infiltrant containing DMAHDM and NACP exhibits potent antibacterial activity against S. mutans and Ca2+ and PO4 (3-) ionic release.