Function of histamine-driven cancer-associated fibroblast and hepatocyte growth factor in the progression of cholangiocarcinoma
The HA-HRH2 signaling pathway mediates the proliferation and secretion of HGF in CAFs. HIF-1α and FOSL1 played crucial roles in driving the proliferation, invasion, and migration of cholangiocarcinoma cells within the tumor microenvironment, orchestrated by CAFs. Furthermore, this study has provided theoretical support for the application of the HA receptor HRH2 inhibitor, Cimetidine, and the HGF receptor cellular mesenchymal-epithelial transition factor (c-MET) inhibitor, Capmatinib, in biliary tract tumors.
Authors
- Xin Wang (ORCID: https://orcid.org/0009-0007-5146-2570)
- Yongchang Tang (ORCID: https://orcid.org/0009-0006-8800-6782)
- Anda Shi (ORCID: https://orcid.org/0009-0009-3705-8314)
- Guoli Sheng
- Zengli Liu (ORCID: https://orcid.org/0009-0001-3902-0936)
- Guangzhen Li (ORCID: https://orcid.org/0000-0002-8812-5558)
- Zhangdi Yan
- Zongli Zhang (ORCID: https://orcid.org/0000-0002-9501-3757)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Gastroenterology report
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gastro/goaf090
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shandong University
- National Natural Science Foundation of China