Study of resistance in strains of Enterobacteriaceae isolated at CeDReS (Treichville University Hospital Center), from November 2012 to November 2019

Emergence and multiplication of antibiotic-resistant bacteria is a public health problem. It appears necessary to regularly update data on the resistance of germs isolated in practitioners' environments. Among pathogenic bacteria, Enterobacteriaceae represent a major clinical threat due to their multidrug resistance, driven in large part by the production of β-lactamases. The aim of this study was to investigate the antibiotic resistance of Enterobacteria strains isolated at the Center for Diagnosis and Research on Acquired Immunodeficiency Syndrome (AIDS) and Other Infectious Diseases (CeDReS) at University Hospital Center of Treichville, from November 2012 to November 2019. A total of 2661 strains of Enterobacteriaceae were isolated. The most frequent species were, in order: Escherichia coli (65.6%), Klebsiella pneumoniae (27.9%) and Enterobacter cloacae (6.5%). Imipenem, latamoxef, amikacin, and colistin exhibited the highest efficacy against E. coli and K. pneumoniae. Significant proportions of extended-spectrum beta-lactamases (ESBLs) were detected at rates of 36.7 and 56%, respectively. The activity of imipenem, amikacin and colistin was very good on E. cloacae strains, with 33.5% of ESBL. These results suggest the need for ongoing monitoring of bacterial resistance to antibiotics. Key words: Enterobacteriaceae, antibiotics, bacterial resistance.